Description
Common side effects include sleepiness, depression, headaches, feeling tired, dry mouth, and memory problems.[3] Some of the sedation and tiredness may improve within a few days.[8] Due to concerns about misuse, some do not recommend alprazolam as an initial treatment for panic disorder.[9] Withdrawal or rebound symptoms may occur if use is suddenly decreased.[3] Other rare risks include suicide, possibly due to loss of inhibition.[10] Gradually decreasing the dose over weeks or months may be required.[6] Alprazolam, like other benzodiazepines, acts through the GABAA receptor.[3]
Alprazolam was patented in 1971 and approved for medical use in the United States in 1981.[3][11] Alprazolam is a Schedule IV controlled substance and is a common drug of abuse.[1][12] It is available as a generic medication.[13] The wholesale cost in the United States is less than US$0.03 per dose as of 2018.[14] In 2017, it was the 21st most commonly prescribed medication in the United States, with more than 25 million prescriptions.[15][16]
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